Normalizing or not normalizing? An open question for floating-point arithmetic in embedded systems

Emerging embedded applications lack of a specific standard when they require floating-point arithmetic. In this situation they use the IEEE-754 standard or ad hoc variations of it. However, this standard was not designed for this purpose. This paper aims to open a debate to define a new extension of the standard to cover embedded applications. In this work, we only focus on the impact of not performing normalization. We show how eliminating the condition of normalized numbers, implementation costs can be dramatically reduced, at the expense of a moderate loss of accuracy. Several architectures to implement addition and multiplication for non-normalized numbers are proposed and analyzed. We show that a combined architecture (adder-multiplier) can halve the area and power consumption of its counterpart IEEE-754 architecture. This saving comes at the cost of reducing an average of about 10 dBs the Signal-to-Noise Ratio for the tested algorithms. We think these results should encourage researchers to perform further investigation in this issue.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Unbiased Rounding for HUB Floating-point Addition

Copyright (c) 2018 IEEE doi:10.1109/TC.2018.2807429Half-Unit-Biased (HUB) is an emerging format based on shifting the represented numbers by half Unit in the Last Place. This format simplifies two’s complement and roundto- nearest operations by preventing any carry propagation. This saves power consumption, time and area. Taking into account that the IEEE floating-point standard uses an unbiased rounding as the default mode, this feature is also desirable for HUB approaches. In this paper, we study the unbiased rounding for HUB floating-point addition in both as standalone operation and within FMA. We show two different alternatives to eliminate the bias when rounding the sum results, either partially or totally. We also present an error analysis and the implementation results of the proposed architectures to help the designers to decide what their best option are.TIN2013-42253-P, TIN2016-80920-R, JA2012P12-TIC-169

Fast HUB Floating-point Adder for FPGA

Several previous publications have shown the area and delay reduction when implementing real number computation using HUB formats for both floating-point and fixed-point. In this paper, we present a HUB floating-point adder for FPGA which greatly improves the speed of previous proposed HUB designs for these devices. Our architecture is based on the double path technique which reduces the execution time since each path works in parallel. We also deal with the implementation of unbiased rounding in the proposed adder. Experimental results are presented showing the goodness of the new HUB adder for FPGA.TIN2016- 80920-R, JA2012 P12-TIC-1692, JA2012 P12-TIC-147

New Results on Non-normalized Floating-point Formats

Compulsory normalization of the represented numbers is a key requirement of the floating-point standard. This requirement contributes to fundamental characteristics of the standard, such as taking the most of the precision available, reproducibility and facilitation of comparison and other operations. However, it also imposes a high restriction in effectiveness of basic arithmetic operation implementation. In many embedded applications may be worth to sacrifice the benefits of normalization for gaining in implementation metrics. This paper analyzes and measures the effect of removing the normalization requirement in terms of precision and implementation savings for embedded applications. We propose several adder and multiplier architectures to deal with non-normalized floating-point numbers, and quantify the accuracy loss and the improvements in hardware implementation. Our experiments show that it is possible to reduce the area and power consumption up to 78% in ASIC and 50% in FPGA implementations with a reasonable accuracy loss.TIN2016-80920-R, JA2012 P12-TIC-1692, JA2012 P12-TIC-147

Boosting Backward Search Throughput for FM-Index Using a Compressed Encoding

The rapid development of DNA sequencing technologies has demanded for com- pressed data structures supporting fast pattern matching queries. FM-index is a widely-used compressed data structure that also supports fast pattern matching queries. It is common for the exact matching algorithm to be memory bound, resulting in poor performance. Searching several symbols in a single step improves data locality, although the memory bandwidth requirements remains the same. We propose a new data-layout of FM-index, called Split bit-vector, that compacts all data needed to search k symbols in a single step (k-step), reducing both memory movement and computing requirements at the cost of increasing memory footprint.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

TraTSA: A Transprecision Framework for Efficient Time Series Analysis

Time series analysis (TSA) comprises methods for extracting information in domains as diverse as medicine, seismology, speech recognition and economics. Matrix Profile (MP) is the state-of-the-art TSA technique, which provides the most similar neighbor to each subsequence of the time series. However, this computation requires a huge amount of floating-point (FP) operations, which are a major contributor ( 50%) to the energy consumption in modern computing platforms. In this sense, Transprecision Computing has recently emerged as a promising approach to improve energy efficiency and performance by using fewer bits in FP operations while providing accurate results. In this work, we present TraTSA, the first transprecision framework for efficient time series analysis based on MP. TraTSA allows the user to deploy a high-performance and energy-efficient computing solution with the exact precision required by the TSA application. To this end, we first propose implementations of TraTSA for both commodity CPU and FPGA platforms. Second, we propose an accuracy metric to compare the results with the double-precision MP. Third, we study MP’s accuracy when using a transprecision approach. Finally, our evaluation shows that, while obtaining results accurate enough, the FPGA transprecision MP (i) is 22.75 faster than a 72-core server, and (ii) the energy consumption is up to 3.3 lower than the double-precision executions.This work has been supported by the Government of Spain under project PID2019-105396RB-I00, and Junta de Andalucia under projects P18-FR-3433 and UMA18-FEDERJA-197. Funding for open access charge: Universidad de Málaga / CBUA

Looking for Crumbs in the Obesity Forest: Anti-obesity Interventions and Obesity-Associated Cardiometabolic Traits in the Mexican Population. History and Systematic Review With Meta-Analyses

Mexicans and Mexican Americans share culture, genetic background, and predisposition for chronic complications associated with obesity and diabetes making imperative efficacious treatments and prevention. Obesity has been treated for centuries focused-on weight loss while other treatments on associated conditions like gout, diabetes (T2D), and hypertriglyceridemia. To date, there is no systematic review that synthesizes the origin of obesity clinics in Mexico and the efforts to investigate treatments for obesity tested by randomized clinical trials (RCT). We conducted systematic searches in Pubmed, Scopus, and Web of Science to retrieve anti-obesity RCT through 2019 and without an inferior temporal limit. The systematic review included RCT of anti-obesity treatments in the Mexican adult population, covering alternative medicine, pharmacological, nutritional, behavioral, and surgical interventions reporting metabolism-associated traits such as BMI, weight, waist circumference, triglycerides, glucose, among others. Only the studies with at least 3 months of treatment were included in the meta-analyses in order to reduce placebo effects. We found 634 entries, after removal of duplicates and screening the studies based on eligibility criteria, we analyzed 43 national, and 2 multinational-collaborative studies. Most of the national studies had small sample sizes, and the implemented strategies do not have replications in the population. The nutrition/behavioral interventions were difficult to blind, and most studies have medium-to-high risk of bias. Nutritional/behavioral interventions and medications showed effects on BMI, waist circumference, and blood pressure. Simple measures like pure water instead of sweet beverages decrease triglycerides and systolic blood pressure. Dark chocolate showed the highest effect for BMI and high blood pressure, and treatment with insulin increased weight in those with T2D. The study of obesity in Mexico has been on-going for more than four decades, the interest on RCT just increased until this millennium, but with small sample sizes and lack of replication. The interventions affect different cardiometabolic associated traits, which should be analyzed in detail in the population living near the Mexico-U.S. border; therefore, bi-national collaboration is desirable to disentangle the cultural effects on this population\u27s treatment response

Effectiveness and safety of anti-CGRP monoclonal antibodies in patients over 65 years: a real-life multicentre analysis of 162 patients

Background Anti-CGRP monoclonal antibodies have shown notable effectiveness and tolerability in migraine patients; however, data on their use in elderly patients is still lacking, as clinical trials have implicit age restrictions and real-world evidence is scarce. In this study, we aimed to describe the safety and effectiveness of erenumab, galcanezumab and fremanezumab in migraine patients over 65 years old in real-life. Methods In this observational real-life study, a retrospective analysis of prospectively collected data from 18 different headache units in Spain was performed. Migraine patients who started treatment with any anti-CGRP monoclonal antibody after the age of 65 years were included. Primary endpoints were reduction in monthly migraine days after 6 months of treatment and the presence of adverse effects. Secondary endpoints were reductions in headache and medication intake frequencies by months 3 and 6, response rates, changes in patient-reported outcomes and reasons for discontinuation. As a subanalysis, reduction in monthly migraine days and proportion of adverse effects were also compared among the three monoclonal antibodies. Results A total of 162 patients were included, median age 68 years (range 65-87), 74.1% women. 42% had dyslipidaemia, 40.3% hypertension, 8% diabetes, and 6.2% previous cardiovascular ischaemic disease. The reduction in monthly migraine days at month 6 was 10.17.3 days. A total of 25.3% of patients presented adverse effects, all of them mild, with only two cases of blood pressure increase. Headache and medication intake frequencies were significantly reduced, and patient-reported outcomes were improved. The proportions of responders were 68%, 57%, 33% and 9% for reductions in monthly migraine days >= 30%,>= 50%,>= 75% and 100%, respectively. A total of 72.8% of patients continued with the treatment after 6 months. The reduction in migraine days was similar for the different anti-CGRP treatments, but fewer adverse effects were detected with fremanezumab (7.7%). Conclusions Anti-CGRP mAbs are safe and effective treatments in migraine patients over 65 years old in real-life clinical practice

Randomized Clinical Trials of obesity treatments in Mexican population. Systematic Review and Meta-Analysis

Background: Mexicans and Mexican Americans share similar culture, genetic background, and predisposition for obesity and diabetes. Randomized clinical trials (RCT) assessing obesity treatments (ObT) are reliable to assess efficacy. To date, there is no systematic review to investigate ObT tested by RCT in Mexican adults. Methods: We conducted systematic searches in Pubmed, Scopus, and Web of Science to retrieve ObT RCT from 1990 to 2019. The ObT included alternative medicine, pharmacological, nutritional, behavioral, and surgical interventions. The analyzed RCT were at least three months of duration, and reported: BMI, weight, waist circumference, triglycerides, glucose and blood pressure. Results: We found 634 entries; after removal of duplicates and exclusions based on eligibility criteria, we analyzed 43 and 2 multinational-collaborative studies. Most of the national studies had small sample sizes, and did not have replications from other studies. The nutrition/behavioral interventions were difficult to blind, and most studies had medium to high risk of bias. Random effects meta-analysis of nutritional/behavioral interventions and medications showed effects on BMI, waist circumference, and blood pressure. Simple measures like plain water instead of sweet beverages decreased triglycerides and systolic blood pressure. Participants with obesity and hypertension had beneficial effects with antioxidants, and the treatment with insulin increased weight in those with T2D. Conclusions: The RCT’s in Mexico reported effects on metabolic components despite small sample sizes and lack of replication. In the future we should analyze ObT in population living on the U.S.-Mexico border; therefore, bi-national collaboration is desirable to disentangle cultural effects on ObT response

Clinical and pathological characteristics of peripheral T‐cell lymphomas in a Spanish population: a retrospective study

We investigated the clinicopathological features and prognostic factors of patients with peripheral T-cell lymphoma (PTCL) in 13 sites across Spain. Relevant clinical antecedents, CD30 expression and staining pattern, prognostic indices using the International Prognostic Index and the Intergruppo Italiano Linfomi system, treatments, and clinical outcomes were examined. A sizeable proportion of 175 patients had a history of immune-related disorders (autoimmune 16%, viral infections 17%, chemo/radiotherapy-treated carcinomas 19%). The median progression-free survival (PFS) and overall survival (OS) were 7·9 and 15·8 months, respectively. Prognostic indices influenced PFS and OS, with a higher number of adverse factors resulting in shorter survival (P 15% of cells were positive in anaplastic lymphoma kinase-positive and -negative anaplastic large-cell lymphoma and extranodal natural killer PTCL groups. We observed PTCL distribution across subtypes based on haematopathological re-evaluation. Poor prognosis, effect of specific prognostic indices, relevance of histopathological sub-classification, and response level to first-line treatment on outcomes were confirmed. Immune disorders amongst patients require further examination involving genetic studies and identification of associated immunosuppressive factors